Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey
Identifieur interne : 002071 ( Main/Exploration ); précédent : 002070; suivant : 002072Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey
Auteurs : Stefano Masi [Royaume-Uni] ; Nikolaos Gkranias [Royaume-Uni] ; KAWA LI [Royaume-Uni] ; Klelia D. Salpea [Royaume-Uni] ; Mohamed Parkar [Royaume-Uni] ; Marco Orlandi [Royaume-Uni] ; Jean E. Suvan [Royaume-Uni] ; Heng L. Eng [Royaume-Uni] ; Stefano Taddei [Royaume-Uni] ; Kalpesh Patel [Royaume-Uni] ; Ulpee Darbar [Royaume-Uni] ; Nikos Donos [Royaume-Uni] ; John E. Deanfield [Royaume-Uni] ; Steve Hurel [Royaume-Uni] ; Steve E. Humphries [Royaume-Uni] ; Francesco D'Aiuto [Royaume-Uni]Source :
- Diabetes care [ 0149-5992 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association, Diabète, Nutrition, Homme.
English descriptors
- KwdEn :
Abstract
OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.
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Deanfield</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Vascular Physiology Unit, Institute of Cardiovascular Science, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Hurel, Steve" sort="Hurel, Steve" uniqKey="Hurel S" first="Steve" last="Hurel">Steve Hurel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Endocrinology, University College London Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="D Aiuto, Francesco" sort="D Aiuto, Francesco" uniqKey="D Aiuto F" first="Francesco" last="D'Aiuto">Francesco D'Aiuto</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0109613</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0109613 INIST</idno><idno type="RBID">Pascal:14-0109613</idno><idno type="wicri:Area/PascalFrancis/Corpus">000006</idno><idno type="wicri:Area/PascalFrancis/Curation">000690</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000005</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000005</idno><idno type="wicri:doubleKey">0149-5992:2014:Masi S:association:between:short</idno><idno type="wicri:Area/Main/Merge">002079</idno><idno type="wicri:Area/Main/Curation">002071</idno><idno type="wicri:Area/Main/Exploration">002071</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey</title><author><name sortKey="Masi, Stefano" sort="Masi, Stefano" uniqKey="Masi S" first="Stefano" last="Masi">Stefano Masi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Vascular Physiology Unit, Institute of Cardiovascular Science, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gkranias, Nikolaos" sort="Gkranias, Nikolaos" uniqKey="Gkranias N" first="Nikolaos" last="Gkranias">Nikolaos Gkranias</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kawa Li" sort="Kawa Li" uniqKey="Kawa Li" last="Kawa Li">KAWA LI</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Salpea, Klelia D" sort="Salpea, Klelia D" uniqKey="Salpea K" first="Klelia D." last="Salpea">Klelia D. Salpea</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Parkar, Mohamed" sort="Parkar, Mohamed" uniqKey="Parkar M" first="Mohamed" last="Parkar">Mohamed Parkar</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Orlandi, Marco" sort="Orlandi, Marco" uniqKey="Orlandi M" first="Marco" last="Orlandi">Marco Orlandi</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Suvan, Jean E" sort="Suvan, Jean E" uniqKey="Suvan J" first="Jean E." last="Suvan">Jean E. Suvan</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eng, Heng L" sort="Eng, Heng L" uniqKey="Eng H" first="Heng L." last="Eng">Heng L. Eng</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Taddei, Stefano" sort="Taddei, Stefano" uniqKey="Taddei S" first="Stefano" last="Taddei">Stefano Taddei</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Patel, Kalpesh" sort="Patel, Kalpesh" uniqKey="Patel K" first="Kalpesh" last="Patel">Kalpesh Patel</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Darbar, Ulpee" sort="Darbar, Ulpee" uniqKey="Darbar U" first="Ulpee" last="Darbar">Ulpee Darbar</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Donos, Nikos" sort="Donos, Nikos" uniqKey="Donos N" first="Nikos" last="Donos">Nikos Donos</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Deanfield, John E" sort="Deanfield, John E" uniqKey="Deanfield J" first="John E." last="Deanfield">John E. Deanfield</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Vascular Physiology Unit, Institute of Cardiovascular Science, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Hurel, Steve" sort="Hurel, Steve" uniqKey="Hurel S" first="Steve" last="Hurel">Steve Hurel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Endocrinology, University College London Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="D Aiuto, Francesco" sort="D Aiuto, Francesco" uniqKey="D Aiuto F" first="Francesco" last="D'Aiuto">Francesco D'Aiuto</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Cross sectional study</term><term>Diabetes mellitus</term><term>Endocrinology</term><term>Human</term><term>Length</term><term>Leukocyte</term><term>Metabolic diseases</term><term>Nutrition</term><term>Periodontitis</term><term>Severe</term><term>Surveillance</term><term>Survey</term><term>Telomere</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parodontite</term><term>Association</term><term>Leucocyte</term><term>Diabète</term><term>Télomère</term><term>Longueur</term><term>Grave</term><term>Etude transversale</term><term>Surveillance</term><term>Enquête</term><term>Endocrinologie</term><term>Maladie métabolique</term><term>Nutrition</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term><term>Diabète</term><term>Nutrition</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Masi, Stefano" sort="Masi, Stefano" uniqKey="Masi S" first="Stefano" last="Masi">Stefano Masi</name></region><name sortKey="D Aiuto, Francesco" sort="D Aiuto, Francesco" uniqKey="D Aiuto F" first="Francesco" last="D'Aiuto">Francesco D'Aiuto</name><name sortKey="Darbar, Ulpee" sort="Darbar, Ulpee" uniqKey="Darbar U" first="Ulpee" last="Darbar">Ulpee Darbar</name><name sortKey="Deanfield, John E" sort="Deanfield, John E" uniqKey="Deanfield J" first="John E." last="Deanfield">John E. Deanfield</name><name sortKey="Donos, Nikos" sort="Donos, Nikos" uniqKey="Donos N" first="Nikos" last="Donos">Nikos Donos</name><name sortKey="Eng, Heng L" sort="Eng, Heng L" uniqKey="Eng H" first="Heng L." last="Eng">Heng L. Eng</name><name sortKey="Gkranias, Nikolaos" sort="Gkranias, Nikolaos" uniqKey="Gkranias N" first="Nikolaos" last="Gkranias">Nikolaos Gkranias</name><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name><name sortKey="Hurel, Steve" sort="Hurel, Steve" uniqKey="Hurel S" first="Steve" last="Hurel">Steve Hurel</name><name sortKey="Kawa Li" sort="Kawa Li" uniqKey="Kawa Li" last="Kawa Li">KAWA LI</name><name sortKey="Masi, Stefano" sort="Masi, Stefano" uniqKey="Masi S" first="Stefano" last="Masi">Stefano Masi</name><name sortKey="Orlandi, Marco" sort="Orlandi, Marco" uniqKey="Orlandi M" first="Marco" last="Orlandi">Marco Orlandi</name><name sortKey="Parkar, Mohamed" sort="Parkar, Mohamed" uniqKey="Parkar M" first="Mohamed" last="Parkar">Mohamed Parkar</name><name sortKey="Patel, Kalpesh" sort="Patel, Kalpesh" uniqKey="Patel K" first="Kalpesh" last="Patel">Kalpesh Patel</name><name sortKey="Salpea, Klelia D" sort="Salpea, Klelia D" uniqKey="Salpea K" first="Klelia D." last="Salpea">Klelia D. Salpea</name><name sortKey="Suvan, Jean E" sort="Suvan, Jean E" uniqKey="Suvan J" first="Jean E." last="Suvan">Jean E. Suvan</name><name sortKey="Taddei, Stefano" sort="Taddei, Stefano" uniqKey="Taddei S" first="Stefano" last="Taddei">Stefano Taddei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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